Prioritize fiber-rich foods like veggies, fruit, and whole grains
Their mechanism gives them two major downstream effects of interest: improved glycemic control and weight reduction (due to appetite reduction + slower gastric emptying) plus other possible metabolic benefits
Enhanced insulin secretion is glucose-dependent via potassium-sensitive adenosine triphosphate (K-ATP) channels mediating K + efflux, which close with a rise in intracellular ATP concentration from glucose metabolism
[1] GLP-3 represents a novel generation of research compounds in the anti-obesity and antidiabetic field, characterized by its unique mechanism of action involving the simultaneous activation of three metabolically relevant receptors: the GCG-like peptide-1 receptor (GLP-1R), the glucose-dependent insulinotropic polypeptide receptor (GIPR), and the GCG receptor (GCGR)
Furthermore, a 2026 review published in BMJ Medicine found that people taking GLP-1 medications regained weight significantly faster than those who had lost weight through diet and exercise alone
